'chest-pain-related' is a compound formed in modern English from the words 'chest', 'pain', and 'related'. 'chest' originates from Old English 'cest' (from Proto-Germanic *kistaz) meaning 'box' or 'container' and later used for the thorax; 'pain' originates from Latin 'poena' meaning 'penalty' (via Old French 'peine'); 'related' originates from Latin 'relatus', the past participle of 'referre' (re- 'back' + ferre 'to carry'), via Old French and Middle English.

'chest' came from Old English 'cest' (a box or container) and extended to mean the body part 'thorax' in later English; 'poena' became Old French 'peine' and then Middle English 'peine' before evolving into modern English 'pain'; 'relatus' became Old French and Middle English forms of 'relate' and the adjective 'related'. The modern compound 'chest-pain-related' is a descriptive, medical/clinical formation using these established English words.

Initially, 'chest' primarily referred to a 'box' or 'container' and later also to the body region 'thorax'; 'pain' originally meant 'punishment' or 'penalty' and shifted to bodily suffering; 'related' initially meant 'brought back' (as a past participle of 'referre') and evolved into the sense 'connected', which is used in the current compound to mean 'connected with chest pain'.