'non-chest-pain-related' originates from Modern English, formed by combining the prefix 'non-' (from Latin 'non' meaning 'not'), the noun 'chest' (Old English 'cest'), the noun 'pain' (from Old French 'peine', ultimately Latin 'poena'), and the adjective 'related' (from Latin 'relatus' via Late Latin/Old French).

'non-' is a productive negative prefix imported into Modern English from Latin; 'chest' comes from Old English 'cest' and developed into the modern noun 'chest'; 'pain' evolved from Old French 'peine' (Latin 'poena'); 'related' derives from Latin 'relatus' (past participle of 'referre') and entered English via Old French/Latin forms, eventually forming the adjective 'related'. The compound itself is a modern English formation used especially in clinical or technical contexts.

The compound was coined in modern English with the literal meaning 'not related to chest pain' for clarity in medical/clinical descriptions; its meaning remains literal and specific.