'antilithogenic' originates from Greek-derived elements used in modern medical English: the prefix 'anti-' meaning 'against', Greek 'lithos' meaning 'stone', and the combining form '-genic' meaning 'producing'.

'antilithogenic' was formed in modern medical terminology by combining 'anti-' with 'lithogenic' (from Greek 'lithos' + '-genic'); the compound construction became used in 19th–20th century clinical and biochemical contexts.

Initially and historically it has meant 'acting against stone formation'; this core meaning has remained stable into current medical usage.