'antiandrogen' originates from Modern English, composed of the prefix 'anti-' (from Greek 'anti-' meaning 'against') and 'androgen' (from Neo-Latin/Modern formation 'androgen' meaning 'male-producing hormone').

'androgen' comes from Greek 'anḗr, andrós' ('man') + suffix from Greek '-genēs' ('begetting, producing'), passed into Neo-Latin and then Modern English as 'androgen'; the prefix 'anti-' was attached in Modern English usage (20th century) to form 'antiandrogen'.

Initially the elements meant 'against' + 'that which generates males'; over time the compound came to mean specifically 'a substance that opposes the action of male hormones (androgens)' and has retained that medical sense.