'antiandrogenic' originates from Greek-derived elements: the prefix 'anti-' (Greek, meaning 'against') + 'androgen' (from Greek 'andr-' meaning 'male' and '-gen' meaning 'producer' or 'that which generates') plus the adjectival suffix '-ic' (from Greek/Latin).

'antiandrogenic' developed from the formation of the noun 'antiandrogen' (a substance that opposes androgens) with the addition of the suffix '-ic' to make an adjective; 'androgen' itself is a modern formation from Greek elements 'andr-' + '-gen'.

Initially it carried the literal sense of 'against androgens' (i.e., opposing male hormones); over time it came to be used specifically in medicine and biology to describe drugs, actions, or properties that block or antagonize androgen effects.