'achirally' originates from Modern English, specifically from the adjective 'achiral' plus the adverbial suffix '-ly'; 'achiral' itself is formed with the prefix 'a-' (from Greek 'a-' meaning 'not') and 'chiral', where 'chiral' ultimately comes from Greek 'kheir' meaning 'hand'.

'achirally' developed from the adjective 'achiral' (formed from 'chiral' coined in the late 19th century from Greek 'kheir' 'hand' and the negating prefix 'a-') by the addition of the adverbial '-ly' to create the adverb meaning 'in a nonchiral way'.

Initially, related forms meant 'not having handedness' (i.e., not chiral); over time the adverbial form 'achirally' has come to mean 'in a manner lacking chirality' and is used in chemistry to describe behavior or properties that show no chirality.