'vasomegaly' originates from New Latin/modern medical coinage, combining Latin 'vas' (from Latin) and the Greek-derived element '-megaly' (from Greek 'megas'), where 'vas' meant 'vessel' and 'megas' meant 'large'.

'vasomegaly' developed as a modern medical formation from the combining form 'vaso-' (based on Latin 'vas') plus the Greek-derived suffix '-megaly' (used in medical terms to indicate enlargement), resulting in the compound used in clinical contexts.

Initially it carried the literal sense 'enlargement of vessel(s)' and, in medical usage, this basic meaning has been retained to denote abnormal vessel enlargement.