Langimage
English

pyrogen

|py-ro-gen|

C2

🇺🇸

/ˈpaɪ.rə.dʒən/

🇬🇧

/ˈpaɪ.rəʊ.dʒən/

fever-producer

Etymology
Etymology Information

'pyrogen' originates from New Latin/modern scientific coinage, ultimately from Greek elements: Greek 'pyr' (πῦρ) meaning 'fire' and Greek 'genēs' meaning 'born' or 'producing'.

Historical Evolution

'pyrogen' was formed in scientific/medical usage by combining the Greek root 'pyr-' and the suffix '-gen' (from Greek 'genēs') via New Latin/modern coinage and was adopted into English usage in the 19th century.

Meaning Changes

Initially the components literally conveyed 'producer of fire/heat', but in medical contexts the meaning evolved to 'a substance that produces fever' (internal heat relating to physiology).

Meanings by Part of Speech

Noun 1

a substance that, when introduced into the body or blood, produces fever; broadly, a fever-producing agent (often bacterial or microbial products).

The laboratory tested the solution for pyrogens before using it in injectable drugs.

Synonyms

Noun 2

specifically, bacterial endotoxins or other microbial products that provoke an immune response resulting in fever (used in medical, pharmaceutical, and laboratory contexts).

Endotoxins are common pyrogens found in contaminated intravenous solutions.

Synonyms

Last updated: 2025/10/28 07:16