'non-peptide-linked' originates from Modern English, formed by the negative prefix 'non-' (meaning 'not') + 'peptide' (from Greek root 'peptid-' via scientific Latin/Neo-Latin) + the past-participial adjective 'linked' (from the verb 'link').

'peptide' derives from Greek 'peptos' ('cooked' or 'digested') via Neo-Latin/chemical coinage 'peptid-' in the 19th century; the compound adjective 'non-peptide-linked' is a modern descriptive formation combining 'non-' with established chemical terminology and the past participle 'linked'.

Initially, 'peptide' described digestion-related concepts from Greek, then became a technical chemical term for amide-linked amino acid chains; 'non-peptide-linked' has consistently meant 'not joined by peptide bonds' in technical usage.