'miscreate' originates from English, combining the prefix 'mis-' (from Old English/Germanic 'mis-' meaning 'wrongly' or 'badly') and the verb 'create' (from Latin 'creare' meaning 'to make, produce').

'miscreate' was used in Middle English in forms such as 'miscrēaten'/'miscraten' (a combination of 'mis-' and the verb derived from Latin 'creare'), and over time the spelling and pronunciation regularized into the modern English 'miscreate'.

Initially it meant 'to make badly or wrongly'; over time the verb remained rare and literary, while a related noun sense—'a malformed or monstrous creation'—appeared and both senses became archaic or marked in modern English.