'disease' originates from Old French, specifically the word 'desaise,' where 'des-' meant 'lack of' and 'aise' meant 'ease or comfort.'

'desaise' transformed into the Middle English word 'disease,' and eventually became the modern English word 'disease.'

Initially, it meant 'discomfort or unease,' but over time it evolved into its current meaning of 'a disorder or illness.'