'calculogenic' originates from Neo-Latin/modern formation combining Latin 'calculus' (meaning 'small stone') and the Greek-derived combining form '-genic' (meaning 'producing' or 'originating').

'calculogenic' was formed from Latin 'calculus' (used in Late/Medieval Latin to mean a small stone, also used for counting pebbles) plus the Greek-derived suffix '-genic' (via Neo-Latin 'calculogenicus'), and entered English as a technical adjective in medical/clinical contexts.

Initially associated with 'small stone' (calculus) and the notion of production or origin; over time it came to be used specifically to describe processes or conditions that produce or are caused by bodily stones (calculi).