'antisialagogue' originates from Greek elements via Modern Latin/medical New Latin: 'anti-' (against) + Greek 'sialon' (σῑάλον, 'saliva') + Greek 'agogos' (ἄγωγος, 'leading' or 'bringing').

'antisialagogue' was formed in post-classical medical Latin/Modern English from Greek roots (compare New Latin/medical coinage 'antisialagogus'), and entered English medical usage in the 19th century as a technical term.

Initially a coinage combining roots meaning 'against saliva-leading,' and it has retained that specialized medical meaning of 'inhibiting salivation' in modern usage.