'antipathetic' originates from Greek via Latin and French, specifically from Greek 'antipathēs' where 'anti-' meant 'against' and 'pathēs' (from 'pathos') related to 'feeling, suffering'.

'antipathetic' came into English from Late Latin/Medieval Latin 'antipathicus' and Old French/Medieval French forms (e.g. 'antipathique'), derived from Greek 'antipathēs', eventually becoming modern English 'antipathetic'.

Initially it meant 'having an opposite or contrary feeling' (literally 'against feeling'), and over time it came to be used chiefly to mean 'showing dislike or aversion' or 'incompatible/opposed'.