'antiaggregant' originates from a modern combination of Greek and Latin elements: the Greek prefix 'anti-' and the Latin verb 'aggregare', where 'anti-' meant 'against' and 'aggregare' meant 'to gather together or add to'.

'antiaggregant' was influenced by Romance-language medical usage (e.g. French 'antiagrégant') and entered modern English in medical contexts; the root 'aggregate' itself came from Latin 'aggregare' (ad- + 'gregare' from 'grex' meaning 'flock') via Old/Middle French into English.

Initially, the components literally meant 'against bringing together'; over time the compound specialized in medicine to mean 'an agent that prevents (platelet) clumping or aggregation'.