N-deacylated
|N-de-a-cy-la-ted|
/ˌɛn.diːˈeɪ.sɪ.leɪ.tɪd/
(N-deacylate)
removed acyl from N
Etymology
'N-deacylated' is formed from the prefix 'N-' (denoting a nitrogen atom) plus 'deacylated', itself from the verb 'deacylate'. 'De-' originates from Latin 'de-' meaning 'off, away, remove', and 'acyl' comes from Modern Latin/French 'acyl(e)' (from New Latin 'acylius'), referring to a radical derived from an acid.
'deacylate' developed in chemical nomenclature by combining the Latin prefix 'de-' with 'acyl' (the term for an acid-derived radical). Over time the verbal form 'deacylate' gave rise to adjectival and participial forms such as 'deacylated'; adding the locational prefix 'N-' produced 'N-deacylated'.
Initially used in technical chemistry contexts simply to indicate removal of an acyl group; it has retained this specific chemical meaning and is now routinely used to specify removal from the nitrogen ('N-') position.
Meanings by Part of Speech
Verb 1
to remove an acyl group from the nitrogen atom of (a molecule); to perform N-deacylation.
After enzymatic treatment, several molecules were N-deacylated and characterized by mass spectrometry.
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Adjective 1
having had an acyl group removed from a nitrogen atom of a molecule; describing a molecule from which an N-linked acyl group has been removed.
The N-deacylated metabolite showed reduced bioactivity compared with the parent compound.
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Last updated: 2025/11/23 00:09