'vesiculate' originates from Latin, specifically the word 'vesicula', where 'vesica' meant 'bladder' or 'small sac'.

'vesiculate' changed from the Medieval Latin form 'vesiculatus' (past participle of vesiculare) and entered English via scientific/medical Latin, becoming the modern English word 'vesiculate' and its adjectival/past forms like 'vesiculated'.

Initially, it meant 'to form or possess small bladders or sacs' in a literal, medical or botanical sense; this meaning has been retained but is mainly used in technical or descriptive contexts today.