'vasospastic' originates from modern medical formation combining Latin and Greek roots: specifically Latin 'vas' where 'vas' meant 'vessel' and Greek 'spasmos' where 'spasmos' meant 'a drawing, convulsion or spasm'.

'vasospastic' changed from the medical noun 'vasospasm' (formed in New/Modern Latin from Latin 'vas' + Greek 'spasmos') and the adjective was formed in English by adding the adjectival ending (‑ic/‑tic) to produce the modern English 'vasospastic'.

Initially it referred directly to the phenomenon 'vasospasm' (the spasm of a blood vessel); over time the adjectival form 'vasospastic' came to describe conditions, tissues, or events characterized by or prone to such spasms.