'vasoregulatory' is formed from the combining form 'vaso-' and the adjective 'regulatory'. 'Vaso-' originates from Latin 'vas, vasis' meaning 'vessel', and 'regulatory' derives from Latin 'regulare' (from 'regere') meaning 'to rule' or 'to guide'.

'vaso-' (from Latin 'vas') was used as a combining form in scientific English to denote 'vessel' (especially blood vessel), and 'regulatory' comes from Late Latin 'regulatorius' via English 'regulate' + the adjectival suffix '-ory'. These elements were combined in modern scientific usage to form 'vasoregulatory'.

Originally the roots meant 'vessel' and 'to rule/guide'; over time the compound came to mean 'pertaining to the control or regulation of blood vessels', a specific physiological sense used in biomedical contexts.