'vasculocidal' originates from New Latin/modern scientific formation: the combining form 'vasculo-' from Latin 'vasculum' meaning 'little vessel' (diminutive of 'vas' meaning 'vessel') and the suffix '-cidal' from Latin '-cidalis'/'-cida' ultimately from 'caedere' meaning 'to kill'.

'vasculocidal' was formed in modern scientific/medical English by combining the prefix 'vasculo-' (related to 'vascul-' as in 'vascular') with the productive suffix '-cidal' (as in 'pesticidal', 'germicidal') to describe agents that kill or destroy vessels.

Initially a coined technical term meaning 'killing vessels' in a literal morphological sense; it has come to be used specifically to describe substances or effects that destroy or damage blood vessels ('destructive to blood vessels').