'unmedicated' originates from the prefix 'un-' meaning 'not' and the word 'medicated' from Latin 'medicatus', meaning 'to heal or cure'.

'medicatus' transformed into the English word 'medicate', and with the addition of the prefix 'un-', it became 'unmedicated'.

Initially, it meant 'not healed or cured with medicine', and this meaning has largely remained the same in modern usage.