'tobacco-opposed' originates from Modern English, specifically it is a compound of 'tobacco' and 'opposed'.

'tobacco' entered English from Spanish 'tabaco', ultimately from a Taino word; 'opposed' comes from Latin 'opponere' via Old French and Middle English, and the compound 'tobacco-opposed' is a modern English formation joining the two words.

Initially the parts meant 'the tobacco plant/product' and 'set against' respectively; as a compound it has the straightforward combined meaning 'against tobacco' and has been used in public-health and policy contexts to describe positions or policies opposed to tobacco.