'systematically-changed' originates from the combination of 'systematic' and 'change', where 'systematic' comes from the Greek 'systēmatikos', meaning 'pertaining to a system', and 'change' from the Old French 'changier', meaning 'to alter'.

'systematic' evolved from the Greek 'systēmatikos' through Latin 'systematicus', and 'change' from Old French 'changier', eventually forming the modern English term 'systematically-changed'.

Initially, 'systematic' meant 'pertaining to a system', and 'change' meant 'to alter'. Together, they evolved to mean 'altered in a methodical manner'.