'strain-dependent' originates from the combination of 'strain,' referring to a genetic variant or subtype of a microorganism, and 'dependent,' meaning contingent upon or influenced by.

The term 'strain' has been used in microbiology since the 19th century, while 'dependent' has been part of the English language since the 14th century. The combination 'strain-dependent' emerged in scientific literature in the late 20th century.

Initially, 'strain-dependent' was used in scientific contexts to describe variations in microorganisms. This meaning has largely remained the same in modern usage.