'spermatogonial' originates from New Latin (scientific usage), ultimately built from Greek elements: 'sperma' meaning 'seed' and 'gonia' (or related roots) meaning 'generation/offspring', via the New Latin noun 'spermatogonium' plus the adjectival suffix '-al'.

'spermatogonium' entered scientific Latin in the 19th century from Greek roots ('sperma' + 'gonia'); the adjective 'spermatogonial' was formed by adding English/Latin adjectival '-al' to denote 'pertaining to spermatogonia'.

Initially used in morphology and embryology to name the 'seed-generation' cells (spermatogonia); it has retained the specialized biological meaning of 'relating to spermatogonia' in modern usage.