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English

pseudoallergic

|pseu-do-al-ler-gic|

C2

🇺🇸

/ˌsuːdoʊəˈlɝdʒɪk/

🇬🇧

/ˌsjuːdəʊəˈlɜːdʒɪk/

allergy-like but not immune-mediated

Etymology
Etymology Information

'pseudoallergic' is formed from the combining elements 'pseudo-' (from Greek 'pseudes', meaning 'false') + 'allergic' (from 'allergy', itself coined from Greek roots 'allos' 'other' + 'ergon' 'work' via German 'Allergie').

Historical Evolution

'allergy' was coined in the early 20th century (Clemens von Pirquet, 1906) from Greek elements and German medical usage; the prefix 'pseudo-' has been attached in medical literature later in the 20th century to indicate 'allergy‑like but not true allergy', producing 'pseudoallergic' as a clinical descriptor.

Meaning Changes

Originally the components conveyed 'false' + 'other/response', and over time the compound came to mean 'an allergy‑like reaction that is not mediated by the immune system' rather than a deliberately 'false' phenomenon.

Meanings by Part of Speech

Adjective 1

resembling an allergic reaction but not caused by immune (IgE‑ or cell‑mediated) mechanisms; an allergic‑like response produced by nonimmunologic processes (for example, direct mast cell activation or complement activation).

The patient developed pseudoallergic symptoms after taking the contrast agent, even though allergy tests were negative.

Synonyms

Antonyms

Last updated: 2025/12/29 03:20