'nonimmunological' originates from English, specifically by combining the negative prefix 'non-' and the adjective 'immunological', where 'non-' meant 'not' and 'immunological' is derived from Latin 'immunis'.

'nonimmunological' developed by attaching the negative prefix 'non-' (Old English/Proto-Germanic negative elements such as 'ne'/'nān') to 'immunological', which itself comes from 'immunology' (formed in modern English from Latin 'immunis' via French/Medieval Latin roots). Over time 'immunis' > 'immune' > 'immunology' > 'immunological', then 'non-' + 'immunological' produced the modern formation.

Originally Latin 'immunis' meant 'exempt' or 'free (from duty)'; through English development 'immune' came to mean 'protected from disease' and 'immunological' to mean 'relating to the immune system'. 'Nonimmunological' has the current straightforward meaning 'not related to the immune system'.