'nonimmunogenic' originates from English, specifically the prefix 'non-' (from Latin 'non') meaning 'not', combined with 'immunogenic', where 'immunogenic' is formed from 'immune' (from Latin 'immunis' meaning 'exempt') and the suffix '-genic' (from Greek root 'gen-'/'genēs' meaning 'producing' or 'causing').

'immunogenic' was created in modern scientific usage by combining 'immune' (from Latin 'immunis') with the productive suffix '-genic' (from Greek), and later the English negative prefix 'non-' was attached to form 'nonimmunogenic'.

Initially 'immune' meant 'exempt' and 'immunogenic' came to mean 'capable of producing immunity or an immune response'; over time 'nonimmunogenic' has come to mean 'not producing an immune response' in biomedical contexts.