'non-anaphylactogenic' originates from the English negative prefix 'non-' combined with 'anaphylactogenic'; 'anaphylactogenic' is formed from 'anaphylaxis' (from Greek elements) plus the combining form '-genic' (from Greek 'gen-', meaning 'producing').

'anaphylaxis' is a modern medical coinage (early 20th century) from Greek elements 'ana-' + 'phylaxis' (protection); adding '-genic' (Greek-derived, 'producing') yielded 'anaphylactogenic' meaning 'causing anaphylaxis', and the negative prefix 'non-' was later attached to form 'non-anaphylactogenic'.

Initially, 'anaphylactogenic' meant 'producing or causing anaphylaxis'; over time the prefixed form 'non-anaphylactogenic' has been used to indicate the absence of that property — i.e., not producing anaphylaxis.