'non-amide-based' is a modern compound formed from the negative prefix 'non-' (from Latin 'non', meaning 'not'), the chemical term 'amide' (from 19th-century German 'Amid' / French 'amide', ultimately related to 'ammonia'), and the adjective-forming use of 'based' from 'base' (from Old French 'base', Latin 'basis').

'amide' was coined in the 19th century (German 'Amid', French 'amide') to name organic derivatives of ammonia; 'base' comes via Old French from Latin 'basis' and Greek 'basis'. The full compound 'non-amide-based' is a later, descriptive formation used in chemical and materials contexts in the 20th–21st centuries.

Initially, elements like 'amide' referenced derivatives of ammonia; over time 'amide' came to denote the specific organic functional group (-CONH2), and the compound 'non-amide-based' evolved to mean 'not using or containing amide chemistry' in modern technical usage.