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methoxy

|meth-ox-y|

C1

🇺🇸

/ˈmɛθəksi/

🇬🇧

/ˈmɛθɒksi/

–OCH3 substituent / methyl–oxygen group

Etymology
Etymology Information

'methoxy' originates from the chemical combining forms 'methyl' + 'oxy' (the latter from Greek 'oxys', originally meaning 'sharp' but used in chemistry as a combining form related to oxygen).

Historical Evolution

'methoxy' was formed in 19th-century chemical nomenclature by combining 'methyl' and the combining form 'oxy'; earlier related terms included 'methoxyl' (used for the radical) and the prefix 'methoxy-' before stabilizing as the modern term 'methoxy'.

Meaning Changes

Initially it could refer to the 'methoxyl radical' or the idea of a methyl-derived oxygen fragment, but it has come to be used primarily for the substituent (–OCH3) or as a prefix indicating that substituent.

Meanings by Part of Speech

Noun 1

a functional group in organic chemistry consisting of an OCH3 substituent; often written as '–OCH3' and called a methoxy group.

The compound contains a methoxy group at the para position.

Synonyms

–OCH3methoxyl

Adjective 1

containing or bearing a methoxy group; used in compound names as a prefix (e.g., 3-methoxybenzaldehyde).

3-methoxybenzaldehyde is an aromatic aldehyde with a methoxy substituent.

Synonyms

methoxylated

Last updated: 2025/12/07 14:43