'macrophthalmos' originates from New Latin, ultimately built from Greek elements 'makros' and 'ophthalmos', where 'makros' meant 'large' and 'ophthalmos' meant 'eye'.

'macrophthalmos' was formed from the Greek words 'makros' and 'ophthalmos' and was adopted into New Latin/medical Latin before entering modern English as the term 'macrophthalmos'.

Initially it literally meant 'large eye', and over time it has retained that basic meaning as a medical term denoting pathological enlargement of the eyeball.