'macrocephalic' originates from Greek, specifically the word 'makrokephalos,' where 'makro-' meant 'large' and 'kephalē' meant 'head.'

'makrokephalos' transformed into the French word 'macrocephale,' and eventually became the modern English word 'macrocephalic' through Middle English.

Initially, it meant 'having a large head,' and this meaning has largely remained the same in modern usage.