'lopsided-jawed' originates from English, specifically a compound of 'lopsided' and 'jaw', where 'lopsided' meant 'tilted to one side' and 'jaw' meant 'the lower facial bone or mouth region'.

'lopsided' developed in early Modern English from 'lop' + 'side' + adjectival suffix '-ed'; 'jaw' appears in Middle English as 'jawe' and became the modern form 'jaw'; the compound 'lopsided-jawed' is a later English coinage combining the two elements to describe jaw shape.

Initially, the elements referred separately to a tilt ('lopsided') and the facial structure ('jaw'); combined, they came to mean specifically 'having an uneven jaw', and this descriptive meaning has remained stable.