'karyotypically' originates from modern scientific English, ultimately formed from the noun 'karyotype' (coined from Greek elements), with the adjective-forming suffix '-ic'/'-ical' and the adverbial suffix '-ly'. 'karyotype' itself combines Greek 'karyon' meaning 'nut, kernel, nucleus' and 'typos' meaning 'impression, mark, type'.

'karyotypically' developed from the noun 'karyotype' (early 20th century scientific coinage), then to the adjective 'karyotypic'/'karyotypical', and finally to the adverb 'karyotypically' used to describe something in terms of its karyotype.

Initially, 'karyotype' described the number and visual appearance of chromosomes in a cell; the derived adjective and adverb retained that specific cytogenetic sense, so 'karyotypically' now means 'in terms of karyotype' or 'with respect to chromosome pattern'.