'infixation' originates from English, specifically formed from 'infix' + the suffix '-ation', where the prefix 'in-' comes via Latin meaning 'in' and the root from Latin 'figere' (root 'fix') meant 'to fasten, fix'.

'infix' ultimately comes from Latin 'infigere' (past participle 'infixus'), passed through Medieval/Neo-Latin and was adopted into English; 'infixation' was later formed by adding the nominalizing suffix '-ation' to denote the process or result.

Initially related to the literal sense 'to fix or fasten in', the term specialized in linguistic contexts to mean 'the insertion of an affix into the interior of a word'.