'hyperkeratotic' originates from Greek, specifically the word 'hyperkeratosis,' where 'hyper-' meant 'over' and 'keratosis' referred to 'horny tissue or skin.'

'hyperkeratosis' transformed into the English adjective 'hyperkeratotic' to describe conditions related to or characterized by hyperkeratosis.

Initially, it meant 'related to excessive keratin production,' and this meaning has largely remained the same in modern usage.