'histaminic' originates from English, specifically from the word 'histamine' with the adjectival suffix '-ic', where 'histamine' itself comes from Greek 'histos' meaning 'tissue' and the element 'amine' referring to an amine (a nitrogen-containing compound).

'histaminic' was formed in English in the early 20th century by adding the suffix '-ic' (from Late Latin/Greek '-ikos') to 'histamine' (a term coined around the 1910s), producing the adjective used in pharmacology and physiology.

Initially it meant 'of or relating to the chemical histamine', but over time it has also been used specifically to mean 'causing or promoting the release of histamine' in medical contexts.