'fatigue-prevention' is a compound of the English words 'fatigue' and 'prevention'. 'fatigue' originates from French, specifically the word 'fatigue', ultimately from Latin 'fatigare', where 'fatigare' meant 'to weary or tire'. 'prevention' originates from Latin, specifically the word 'praeventio' (from 'praevenire'), where the prefix 'prae-' meant 'before' and 'venire' meant 'to come'.

'fatigue' entered English via French ('fatigue') in Middle English and retained its meaning of weariness; 'prevention' came into English via Old French from Latin 'praeventio' and developed into the modern English 'prevention'. The compound 'fatigue prevention' is a transparent modern English formation combining the two nouns.

Individually, 'fatigue' initially meant 'weariness' and 'prevention' meant 'the act of preventing'; together the compound evolved in modern usage to denote organized measures or policies designed specifically to stop or reduce weariness ('fatigue').