'euphorigenic' originates from New Latin/Greek, specifically from the Greek noun 'euphoria' (Greek: 'εὐφορία'), where the prefix 'eu-' meant 'well' and the root related to 'pherein' meant 'to bear', combined with the suffix '-genic' from Greek 'genein' meaning 'to produce'.

'euphorigenic' developed by combining the English/Latin borrowing 'euphoria' (which came into English via New Latin from Greek) with the scientific suffix '-genic' (a modern coinage from Greek roots). 'Euphoria' entered English in the 17th century; the formation of adjectives like 'euphorigenic' arose later as scientific and medical terminology expanded in the 19th–20th centuries.

Initially the roots conveyed the general sense of 'bearing well' or 'well-being'; over time the combined term came to mean specifically 'producing euphoria' or 'producing a sense of intense well-being'.