'dyophysite' originates from Greek, specifically the elements 'dyo' and 'physis', where 'dyo-' meant 'two' and 'physis' meant 'nature', combined with the suffix '-ite' denoting an adherent.

'dyophysite' changed from ecclesiastical/Medieval Latin and Greek usage (e.g. Medieval Latin dyophysita) and eventually became the modern English word 'dyophysite' through theological literature.

Initially, it meant 'one who affirms two natures (in Christ)', and over time it has remained a technical theological term with essentially the same meaning.