'domesticity-averse' is a modern compound combining 'domesticity' and 'averse'. 'domesticity' comes from 'domestic' + the noun-forming suffix '-ity', and 'averse' comes from Latin 'aversus' (see below).

'domestic' originates from Latin 'domesticus' (from 'domus' meaning 'house'); 'domesticity' was formed in English by adding the suffix '-ity' to 'domestic'. 'averse' comes from Latin 'aversus', past participle of 'avertere' ('ab-' away + 'vertere' to turn). The modern hyphenated compound 'domesticity-averse' is a 19th–21st century English formation modeling other '-averse' compounds (e.g., 'risk-averse').

Initially, the parts meant 'relating to the house' ('domesticity') and 'turned away' ('averse'); together as a compound they evolved to mean 'turned away from domestic life' or simply 'disliking domesticity'.