'disease-preventing' originates from Modern English, specifically the combination of 'disease' and 'preventing'; 'disease' ultimately comes from Old French 'desaise' (from des- 'not' + aise 'ease'), and 'preventing' derives from Latin 'praevenire' (prae- 'before' + venire 'to come') via Old French 'prevenir'.

'disease' changed from Old French 'desaise' to Middle English 'diseas' and eventually became the modern English 'disease'. 'prevent' came from Latin 'praevenire' to Old French 'prevenir' and then Middle English 'prevent', producing the modern participle 'preventing'; the compound adjective 'disease-preventing' arose in Modern English by combining these elements.

Initially, 'disease' meant 'lack of ease' and 'prevent' meant 'to come before or to forestall'; over time their senses shifted toward medical contexts, and the combination came to mean 'acting to stop the occurrence of disease'.