'depletion' originates from Latin, specifically the word 'depletio', where 'de-' meant 'away/completely' and 'plēre' (or root 'plere') meant 'to fill'.

'depletion' changed from the Medieval Latin word 'depletio' (from Latin 'deplēre'/'depletus') and entered English via Middle English/Medieval Latin as 'depletion'.

Initially, it meant 'the action of emptying or removing what filled something'; over time it evolved into the current meaning of 'a reduction or exhaustion of quantity or resources'.