'blood-glucose-lowering' is a modern English compound formed from 'blood' + 'glucose' + 'lowering'. 'blood' originates from Old English 'blōd' (from Proto-Germanic roots) meaning 'blood'; 'glucose' is a 19th-century scientific coinage from Modern Latin/French 'glucosum' ultimately from Greek 'glykys' meaning 'sweet'; 'lowering' is the present-participial form of the verb 'lower' (from Middle English formations of 'low' + verbal suffix).

'glucose' was coined in early 19th-century chemical nomenclature (from Greek 'glykys' via Latin/French) to name a specific sugar; 'blood-glucose' became a routine medical compound to denote glucose in the blood; 'blood-glucose-lowering' arose in 20th-century medical usage to describe agents or effects that reduce blood glucose.

Individually, 'glucose' originally signified 'sweet' in Greek and evolved to mean the specific sugar 'glucose' in chemistry; combined as 'blood-glucose-lowering', the compound specifically denotes the property or action of lowering blood glucose (primarily a medical/pharmacological sense).