'blastosphere' originates from Greek, specifically the words 'blastos' and 'sphaira', where 'blastos' meant 'germ' or 'bud' and 'sphaira' meant 'ball'.

'blastosphere' was formed in modern scientific usage as a compound of Greek roots (blastos- + -sphere) in 20th/21st-century biological literature to name spherical aggregates of embryonic or undifferentiated cells.

Initially, the separate elements literally conveyed a 'germ/bud ball', but over time the compound came to denote a specific scientific concept: a spherical aggregate of embryonic/undifferentiated cells used in developmental biology and cell culture studies.