'azygospore' originates from Modern scientific coinage (New Latin/Neo-Latin), specifically formed from the Greek-derived prefix 'a-' meaning 'not' plus 'zygospore' (from Greek 'zygōn' meaning 'yoke' and 'spora' meaning 'seed, sowing').

'azygospore' was coined by prefixing 'a-' to 'zygospore'; 'zygospore' entered scientific English from Neo-Latin 'zygospora', which itself derives from Greek 'zygōn' ('yoke') + 'spora' ('seed, sowing').

Initially and historically it has meant 'a spore not produced by zygote/sexual fusion'; this technical meaning has been maintained in modern mycological usage.