'axoplasmic' originates from New Latin/Greek, specifically from the word 'axoplasm' formed from Greek 'axōn' ('axis') + Greek 'plasma' ('something formed'), with the English adjective-forming suffix '-ic'.

'axoplasm' was formed in New Latin from Greek elements 'axōn' + 'plasma'; the adjective 'axoplasmic' arose in English by adding the suffix '-ic' to denote 'relating to axoplasm'.

Initially it denoted 'of or relating to the substance of an axon (axoplasm)'; over time it has retained this specialized anatomical/physiological meaning.