'autolyzate' originates from Modern English, specifically formed from the verb 'autolyze' plus the suffix '-ate', where 'auto-' comes from Greek 'autos' meaning 'self' and 'lyein' meant 'to loosen, to dissolve'.

'autolyzate' developed from the Neo-Latin/Greek compound 'autolysis' (from Greek elements) and the 19th-century scientific verb 'autolyze'; the noun form 'autolyzate' emerged in modern scientific English to denote the product of autolysis.

Initially related to the process name 'autolysis' (self-digestion), the term evolved to refer specifically to the material produced by that process — the 'autolyzate' — used in biochemical, food, and microbiological contexts.