'asynergy' is a modern English formation built from the negative prefix 'a-' + the Greek-derived element 'synergy' (from Greek 'synergia' meaning 'working together').

'asynergy' developed from New Latin/medical coinages such as 'asynergia' (used in medical and scientific Latin), which itself combined Greek roots 'a-' (privative) + 'synergia'; it then entered English as 'asynergy'.

The term originally signified simply 'lack of cooperative action'; over time it retained that general sense while also acquiring specific medical usage referring to uncoordinated muscular or organ movement (e.g., cardiac asynergy).